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Microfluidics · 2010

A simple method of fabricating mask-free microfluidic devices for biological analysis

We report a simple, low-cost, rapid, and mask-free method to fabricate two-dimensional (2D) and three-dimensional (3D) microfluidic chip for biological analysis researches. In this fabrication process, a laser system is used to cut through paper to form intricate patterns and differently configured channels for specific purposes.

Performance the paper reports

0 of 5
  1. Motion—Motion accuracy: not reported
  2. Volume—Volumetric accuracy: not reported
  3. Viability—Cell viability: not reported
  4. Unattended—Unattended operation: not reported
  5. Standard—Standard compliance: not reported

The full text was read and states no figure for any of the five.

How hard this is to adopt

3.3 of 5, higher is easier

Each score is shown against the range the other 59 builds actually occupy, because no criterion uses the full 1–5 scale. These describe how reproducible the build is, not how good the science is.

  • Resolution

    3/1–5

    Smallest feature/positioning evidence about 50-100 µm.

  • Throughput

    2/2–5

    Operation appears single-unit or manually constrained.

  • Parts sourcing

    3/2–4

    Part sourcing complexity not explicit; assigned moderate default.

  • Skill needed

    4/2–4

    Build/operation described as low-skill or basic assembly.

  • Facilities needed

    3/2–4

    Requires accessible but nontrivial lab/maker equipment.

  • Documentation

    3/2–5

    Some open documentation or files are available.

  • Validation effort

    4/2–4

    Validation includes standards, benchmarking, replicates, or multi-condition tests.

  • Cycle time

    4/1–4

    Speed evidence suggests rapid, real-time, or automated operation.

2 further criteria are recorded but not shown
  • Application Level — scored 2 (75% of records share one value), so it cannot separate one build from another.
  • Build Time (scored for only 6 of 60 records), so it cannot separate one build from another.

Both remain in the published dataset.

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Record metadata

Publication

Year
2010
Venue
Unknown
DOI
10.1063/1.3487796
Type
Unspecified

Implementation

Open-source
Uncertain
Repository
Not linked
Build complexity
Unspecified
Approximate cost
Unknown
Publication data

Matched by title · retrieved 2026-07-21

Abstract

We report a simple, low-cost, rapid, and mask-free method to fabricate two-dimensional (2D) and three-dimensional (3D) microfluidic chip for biological analysis researches. In this fabrication process, a laser system is used to cut through paper to form intricate patterns and differently configured channels for specific purposes. Full abstract at the publisher

Bibliographic details

Published
2010-09-01
Journal/source
Biomicrofluidics
Publisher
AIP Publishing
DOI
10.1063/1.3487796
Type
journal-article
Language
en
Volume / issue
4 / 3
Pages
Not supplied
ISSN
1932-1058

Access and metrics

Open access
Yes
OA status
bronze
License
Not supplied
Version
publishedVersion
Cited by
23
References
39
Retracted
No

Authors and affiliations

  1. Yi XinHong Kong University of Science and Technology · University of Hong Kong
  2. Rimantas KodziusHong Kong University of Science and Technology
  3. Xiuqing GongHong Kong University of Science and Technology · University of Hong Kong
  4. Kang XiaoHong Kong University of Science and Technology · University of Hong Kong
  5. Weijia WenHong Kong University of Science and Technology · University of Hong Kong

Topics and keywords

Microfluidic and Capillary Electrophoresis ApplicationsBiosensors and Analytical DetectionInnovative Microfluidic and Catalytic Techniques InnovationMicrofluidicsFabricationMaterials scienceNanotechnologyPolymerCapillary actionBiocompatibilityMicrofluidic chipLab-on-a-chipFluidicsCapillary electrophoresisChromatography
Perspective and practical signals

Why it matters

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Limitations

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