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Microscopy & ImagingMicroscopy and imagingSupplemental record

Open-source microscope add-on for structured illumination microscopy

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Matched by doi · retrieved 2026-07-21

Abstract

Super-resolution techniques expand the abilities of researchers who have the knowledge and resources to either build or purchase a system. This excludes the part of the research community without these capabilities. Here we introduce the openSIM add-on to upgrade existing optical microscopes to Structured Illumination super-resolution Microscopes (SIM). The openSIM is an open-hardware system, designed and documented to be easily duplicated by other laboratories, making super-resolution modality accessible to facilitate innovative research. The add-on approach gives a performance improvement for pre-existing lab equipment without the need to build a completely new system.

Bibliographic details

Published
2024-02-20
Journal/source
Nature Communications
Publisher
Springer Science and Business Media LLC
DOI
10.1038/s41467-024-45567-7
Type
journal-article
Language
en
Volume / issue
15 / 1
Pages
Not supplied
ISSN
2041-1723

Access and metrics

Open access
Yes
OA status
gold
License
cc-by
Version
publishedVersion
Cited by
26
References
46
Retracted
No

Authors and affiliations

  1. Mélanie T. M. HannebelleCenter for Innovation · École Polytechnique Fédérale de Lausanne · Stanford University
  2. Esther RaethÉcole Polytechnique Fédérale de Lausanne
  3. Samuel M. LeitãoÉcole Polytechnique Fédérale de Lausanne
  4. Tomáš LukešÉcole Polytechnique Fédérale de Lausanne
  5. Jakub PospíšilCzech Technical University in Prague · UiT The Arctic University of Norway
  6. Chiara TonioloÉcole Polytechnique Fédérale de Lausanne
  7. Olivier F. VenzinÉcole Polytechnique Fédérale de Lausanne
  8. Antonius ChrisnandyÉcole Polytechnique Fédérale de Lausanne
  9. Prabhu Prasad SwainÉcole Polytechnique Fédérale de Lausanne
  10. Nathan RoncerayÉcole Polytechnique Fédérale de Lausanne
  11. Matthias P. LütolfÉcole Polytechnique Fédérale de Lausanne
  12. Andrew C. OatesÉcole Polytechnique Fédérale de Lausanne
  13. Guy M. HagenUniversity of Colorado Colorado Springs
  14. Theo LasserÉcole Polytechnique Fédérale de Lausanne
  15. Aleksandra RađenovićÉcole Polytechnique Fédérale de Lausanne
  16. John D. McKinneyÉcole Polytechnique Fédérale de Lausanne
  17. Georg E. FantnerCorresponding authorÉcole Polytechnique Fédérale de Lausanne

Topics and keywords

Advanced Fluorescence Microscopy TechniquesNear-Field Optical MicroscopyOptical Coherence Tomography ApplicationsUpgradeMicroscopeComputer scienceResolution (logic)Modality (human–computer interaction)Open sourceSoftwareArtificial intelligenceOpticsOperating systemPhysics