Liquid Handling
Papers centered on pipetting, dispensing, pumps, autosamplers, liquid-handling robots, and fluid-transfer workflows.
Why these papers are here
Generated directly from the paper category fields so every paper belongs to at least one topical collection.
A 3D-Printed Plate Handler for Automated Handling of Well Plates on the Opentrons OT-2
Structured record from the DIY biofabrication corpus.
A hackable, multi-functional, and modular extrusion 3D printer for soft materials
Useful adjacent open platform for hydrogel/soft-matter printing; may be bioprinting-enabling.
A high performance open-source syringe extruder optimized for extrusion and retraction during FRESH 3D bioprinting
Directly comparable to Replistruder—an open syringe/extrusion tool that enables better bioink handling.
A low-cost push–pull syringe pump for continuous flow applications
Continuous-flow is a common gap in low-cost pump designs; relevant for automated synthesis and perfusion workflows.
A robot-assisted acoustofluidic end effector
Robot arm + acoustofluidic end effector to do microfluidic-style liquid manipulation and automated mixing.
Adapting a Low-Cost and Open-Source Commercial Liquid Handling Robot for High Throughput Screening
Practical paper showing how open-source hardware is used/adapted in real screening pipelines.
An Open Source Syringe Pump Controller for Fluid Delivery of Multiple Volumes
Control-layer open tool enabling multi-volume delivery; complements open pump hardware papers.
Analytical Measurements and Efficient Process Generation Using a Dual–Arm Robot Equipped with Electronic Pipettes
Dual-arm robot using electronic pipettes for liquid handling in analytical workflows.
Automation of biochemical assays using an open-sourced, inexpensive robotic liquid handler
Structured record from the DIY biofabrication corpus.
BioCloneBot: A versatile, low-cost, and open-source automated liquid handler
One of the clearest recent open-hardware liquid-handling robots with a full paper + accessible full text.
Commit: Digital pipette: open hardware for liquid transfer in self-driving laboratories
Open hardware for accurate liquid transfer in self-driving labs; reports accuracy within ISO 8655-2 permissible error.
Deep integration of low-cost liquid handling robots in an industrial pharmaceutical development environment
Structured record from the DIY biofabrication corpus.
Design and Validation of an Open-Hardware Print-Head for Bioprinting Application
Dedicated open-hardware printhead paper; good historical anchor beyond syringe conversions.
Development of a Robotic System for Automatic Organic Chemistry Synthesis
Robot-arm-based chemistry automation with liquid handling, mixing, filtering—generalizable robot-arm approach.
Evaluation of Microplate Handling Accuracy for Applying Robotic Arms in Laboratory Automation
Quantifies robot-arm positioning requirements for microplate transfer—key enabler around liquid handlers.
Fabrication and validation of an affordable DIY coaxial 3D extrusion bioprinter
Coaxial extrusion expands tool capability (e.g., core–shell) with DIY accessibility.
FINDUS: An Open-Source 3D Printable Liquid-Handling Workstation for Laboratory Automation in Life Sciences
Strong open-source workstation reference with reported pipetting error metrics; useful comparator to OTTO/digital pipette.
Leveraging flexible pipette-based tool changes to transform liquid handling systems into dual-function sample preparation and imaging platforms
Recent (2025) HardwareX paper; highly relevant to modular tool concepts like the digital pipette.
Nydus One Syringe Extruder (NOSE): A Prusa i3 3D printer modification for laboratory automation and syringe-based extrusion
Often referenced for syringe-based extrusion designs; adjacent to extrusion bioprinting toolchains.
Open-source cell culture automation system with integrated cell counting for passaging microplate cultures
Structured record from the DIY biofabrication corpus.
Open-source personal pipetting robots with live-cell incubation and microscopy compatibility
Shows open hardware that integrates pipetting + incubation + imaging, closer to ‘robot-compatible’ liquid handling.
Open-source spring-driven syringe pump with 3D-printed components for microfluidic applications
A 2024 open-hardware pump design; useful building block for low-cost liquid handling and microfluidics.
Open-Source Syringe Pump Library
Not bioprinting-specific, but open syringe-pump hardware is a common building block for extrusion bioprinting. | Foundational open-hardware syringe pump reference frequently reused in lab automation builds.
Open-source, 3D-printed Peristaltic Pumps for Small Volume Point-of-Care Liquid Handling
Enabling open liquid-handling hardware that can integrate with extrusion/bioprinting workflows. | Practical open pump design for point-of-care and microfluidic liquid handling.
OpenLH: Open Liquid-Handling System for Creative Experimentation with Biology
Uses a commercial robotic arm + modified pipette + block-based programming; relevant example of robot-arm liquid handling. | Early ‘open liquid handling’ system description; may provide useful design patterns + references.
OpenWorkstation: A modular open-source technology for automated in vitro workflows
Useful ‘platform’ paper for building modular open lab automation setups beyond a single device.
OT-Mation: an open-source code for parsing CSV files into Python scripts for control of OT-2 liquid-handling robotics
Structured record from the DIY biofabrication corpus.
Principles of computer-controlled linear motion applied to an open-source affordable liquid handler for automated micropipetting
Not a bioprinter, but relevant open automation tool for biofabrication/bioprinting workflows. | Canonical open-source liquid handling robot paper; good baseline against newer modular tools like digital pipette.
PyLabRobot: An open-source, hardware-agnostic interface for liquid-handling robots and accessories
Not hardware itself, but critical open control layer for heterogeneous open liquid-handling setups.
Real-time AI-driven quality control for laboratory automation: a novel computer vision solution for the opentrons OT-2 liquid handling robot
Structured record from the DIY biofabrication corpus.
Replistruder 4
Structured record from the DIY biofabrication corpus.
Sidekick: A Low-Cost Open-Source 3D-printed liquid dispensing robot
HardwareX often includes complete design files + BOM; strong ‘open hardware’ fit.
Slowpoke: An Automated Golden Gate Cloning Workflow for Opentrons OT-2 and Flex
Structured record from the DIY biofabrication corpus.
Soft robotic patterning of liquids
Soft-robotics approach to manipulating/patterning liquids (Scientific Reports). Might be relevant as an alternative actuation/control mechanism for liquid handling, even if not a pipetting robot.
The Enderstruder: An accessible open-source syringe extruder compatible with Ender series 3D printers
Direct Replistruder-like tool: low-cost syringe extruder with shared profiles and OSHW metadata.
Technical upgrade of an open-source liquid handler to support bacterial colony screening
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Automating hESC differentiation with 3D printing and legacy liquid handling solutions
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Automated Liquid Handler from a 3D Printer
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High-Efficiency 3D-Printed Three-Chamber Electromagnetic Peristaltic Micropump
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Highly-customizable 3D-printed peristaltic pump kit
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BoSL FAL pump: A small, low-cost, easily constructed, 3D-printed peristaltic pump for sampling of waters
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EvoBot: An Open-Source, Modular, Liquid Handling Robot for Scientific Experiments
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A Simple Approach for Controlling an Open-Source Syringe Pump
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The FAST Pump, a low-cost, easy to fabricate, SLA-3D-printed peristaltic pump for multi-channel systems in any lab
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Principles of open source bioinstrumentation applied to the poseidon syringe pump system
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An automated and parallelised DIY-dosing unit for individual and complex feeding profiles: Construction, validation and applications
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An open-source programmable smart pipette for portable cell separation and counting
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Adapting a Low-Cost and Open-Source Commercial Pipetting Robot for Nanoliter Liquid Handling
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Building an Arduino-Based Open-Source Programmable Multichannel Syringe Pump: A Useful Tool for Fluid Delivery in Microfluidics and Flow Chemistry
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A User-Centric 3D-Printed Modular Peristaltic Pump for Microfluidic Perfusion Applications
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Utility of low-cost, miniaturized peristaltic and Venturi pumps in droplet microfluidics
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µPump: An open-source pressure pump for precision fluid handling in microfluidics
Supplemental record retained to make the downloaded paper corpus fully navigable.
micrIO: an open-source autosampler and fraction collector for automated microfluidic input–output
Supplemental record retained to make the downloaded paper corpus fully navigable.