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Liquid Handling · Automation · Pipetting/dispensing · 2018 · Energies

Analytical Measurements and Efficient Process Generation Using a Dual–Arm Robot Equipped with Electronic Pipettes

The continued growth in life sciences is being accompanied by the constantly rising demand for robotic systems. Today, bioscreening and high–throughput screening processes are well automated.

Performance the paper reports

0 of 5
  1. Motion—Motion accuracy: not reported
  2. Volume—Volumetric accuracy: not reported
  3. Viability—Cell viability: not reported
  4. Unattended—Unattended operation: not reported
  5. Standard—Standard compliance: not reported

The full text was read and states no figure for any of the five.

How hard this is to adopt

3.1 of 5, higher is easier

Each score is shown against the range the other 59 builds actually occupy, because no criterion uses the full 1–5 scale. These describe how reproducible the build is, not how good the science is.

  • Resolution

    4/1–5

    Electronic pipettes span 5-200 uL and 50-1000 uL, so a 5 uL minimum; 100 uL gave a 95.42 uL mean at 3.79% CV, not sub-uL.

  • Throughput

    3/2–5

    One pipette on one arm forming a single channel, 12 vials per run; dual-pipette parallel operation is explicitly future work rather than demonstrated.

  • Parts sourcing

    4/2–4

    Mostly off-the-shelf or kit-based components.

  • Skill needed

    2/2–4

    Multiple advanced technical skills appear required.

  • Facilities needed

    3/2–4

    Requires accessible but nontrivial lab/maker equipment.

  • Documentation

    2/2–5

    Open build documentation is not clearly identified.

  • Validation effort

    4/2–4

    Gravimetric n=12 at 100 uL and 1300 uL with a direct head-to-head comparison against conventional manual pipettes on the same robot; water only, no drift or carryover testing.

  • Cycle time

    3/1–4

    Total process 11.1 min with electronic versus 12.2 min with manual pipettes (~9% faster, within +/-20%); per-step pipetting is actually 25 s versus 8 s.

2 further criteria are recorded but not shown
  • Application Level — scored 4 (75% of records share one value), so it cannot separate one build from another.
  • Build Time (scored for only 6 of 60 records), so it cannot separate one build from another.

Both remain in the published dataset.

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Publication data

Matched by doi · retrieved 2026-07-21

Abstract

The continued growth in life sciences is being accompanied by the constantly rising demand for robotic systems. Today, bioscreening and high–throughput screening processes are well automated. In contrast, a deficit can be found in the area of analytical measurements with complex and frequently changing processes. Robots undertake not only transportation tasks, but also direct sample manipulation and subsequent analytical measurements. Due to their human-like structure, dual-arm robots perform such processes similar to human operation. Liquid handling is required to transfer chemicals, to prepare standard solutions, or to dilute samples. Two electronic pipettes with different volume ranges (5–200 µL and 50–1000 µL) were integrated into a dual–arm robotic system. The main focus in this publication is the software interface for alternating robot and pipette control as well as the high–level process control system. The performance using a dual–arm robot equipped with electronic pipettes and conventional manual pipettes was determined and compared. The automation system presented is the first integration of a dual-arm robot in analytical measurement processes. Conventional manual laboratory pipettes and electronic pipettes are simultaneously used for liquid-handling tasks. The software control system enables a flexible and user-friendly process generation.

Bibliographic details

Published
2018-09-26
Journal/source
Energies
Publisher
MDPI AG
DOI
10.3390/en11102567
Type
journal-article
Language
en
Volume / issue
11 / 10
Pages
2567
ISSN
1996-1073

Access and metrics

Open access
Yes
OA status
gold
License
cc-by
Version
publishedVersion
Cited by
48
References
26
Retracted
No

Authors and affiliations

  1. Heidi FleischerCorresponding authorUniversity of Rostock
  2. Daniel BaumannUniversity of Rostock
  3. Shalaka JoshiUniversity of Rostock
  4. Xianghua ChuUniversity of Rostock
  5. Thomas RoddelkopfUniversity of Rostock
  6. Michael Klös
  7. Kerstin ThurowUniversity of Rostock

Topics and keywords

Viral Infectious Diseases and Gene Expression in InsectsInnovative Microfluidic and Catalytic Techniques InnovationMicrofluidic and Capillary Electrophoresis ApplicationsPipetteRobotAutomationProcess (computing)SoftwareRobotic armComputer scienceLaboratory automationThroughputInterface (matter)SimulationBiomedical engineering

Funding

  • Bundesministerium für Wirtschaft und Energie · FKZ: ZF4066003DB6
Perspective and practical signals

Why it matters

Dual-arm robot using electronic pipettes for liquid handling in analytical workflows.

Limitations

No limitation note curated yet.