All builds

Liquid Handling · Pipetting/dispensing · Commit: Digital Pipette · 2026 · Digital Discovery

Commit: Digital pipette: open hardware for liquid transfer in self-driving laboratories

Robot-mounted 3D-printed digital pipette for liquid transfer in self-driving labs

Performance the paper reports

2 of 5
  1. Motion—Motion accuracy: not reported
  2. Volume0.2%Volumetric accuracy: reported
  3. Viability—Cell viability: not reported
  4. Unattended—Unattended operation: not reported
  5. StandardISO 8655Standard compliance: reported
  • Volumetric accuracy0.2%
    [curated metric] 0.2% random error at 10 mL nominal volume (ISO 8655-6); meets ISO 8655-2 accuracy range
  • Reported against a written standardISO 8655
    [curated metric] 0.2% random error at 10 mL nominal volume (ISO 8655-6); meets ISO 8655-2 accuracy range

How hard this is to adopt

2.9 of 5, higher is easier

Each score is shown against the range the other 59 builds actually occupy, because no criterion uses the full 1–5 scale. These describe how reproducible the build is, not how good the science is.

  • Resolution

    1/1–5

    Nominal 10 mL air-displacement syringe; ISO tests at 1/5/10 mL with smallest tested 0.2 mL; authors concede uL-level accuracy needs higher-precision actuators.

  • Throughput

    2/2–5

    Single-channel pipette handling one liquid at a time; automated tip exchange but external tip remover and greasing upkeep; no plate or full workflow demonstrated.

  • Parts sourcing

    3/2–4

    Mix of common parts and custom/printed components.

  • Skill needed

    4/2–4

    Build/operation described as low-skill or basic assembly.

  • Facilities needed

    2/2–4

    Requires specialized facilities, equipment, or consumables.

  • Documentation

    4/2–5

    Open resources include several build or operation artifacts.

  • Validation effort

    4/2–4

    ISO 8655-6 gravimetric at three volumes against v1 and ISO limits, plus explicit benchmark against four human pipettors (Levene, p=0.0046); calibration curves given.

  • Cycle time

    3/1–4

    No timing comparison reported; only a 10-minute assembly time, with no aspiration/dispense or cycle-time data versus manual or commercial pipetting.

2 further criteria are recorded but not shown
  • Application Level — scored 4 (75% of records share one value), so it cannot separate one build from another.
  • Build Time — scored 5 (scored for only 6 of 60 records), so it cannot separate one build from another.

Both remain in the published dataset.

Have you built this?

Report what it took, including attempts that stalled. A failed build tells the next laboratory what the documentation leaves out.

Report a rebuild

Know what this record is missing?

The index has no licence on the design files for this build. If you are an author or have built it, you know; a GitHub issue pre-filled with this record takes a minute.

Fill the gap
Record metadata
Publication data

Matched by doi · retrieved 2026-07-21

Abstract

We present an updated version of the digital pipette, an economical 3D-printed device for accurate liquid transfers by robotic arms. The new version supports disposable tip replacement to reduce contamination while maintaining high accuracy.

Bibliographic details

Published
2025-11-19
Journal/source
Digital Discovery
Publisher
Royal Society of Chemistry (RSC)
DOI
10.1039/d5dd00336a
Type
journal-article
Language
en
Volume / issue
5 / 1
Pages
93-97
ISSN
2635-098X

Access and metrics

Open access
Yes
OA status
diamond
License
cc-by
Version
publishedVersion
Cited by
0
References
7
Retracted
No

Authors and affiliations

  1. Naruki YoshikawaCorresponding authorUniversity of Toronto · Vector Institute · Institute of Science Tokyo
  2. Kevin AngersUniversity of Toronto
  3. Kourosh DarvishUniversity of Toronto · Structural Genomics Consortium · Vector Institute
  4. Sargol OkhovatianUniversity of Toronto · Toronto Rehabilitation Institute · Toronto General Hospital
  5. Dawn BannermanUniversity of Toronto · Toronto Rehabilitation Institute · Toronto General Hospital
  6. Ilya YakavetsUniversity of Toronto · Structural Genomics Consortium
  7. Milica RadisicCorresponding authorUniversity of Toronto · Toronto Rehabilitation Institute · Toronto General Hospital · Structural Genomics Consortium
  8. Alán Aspuru-GuzikCorresponding authorCanadian Institute for Advanced Research · University of Toronto · Structural Genomics Consortium · Vector Institute

Topics and keywords

Experimental Learning in EngineeringElectrowetting and Microfluidic TechnologiesExperimental and Theoretical Physics StudiesTransfer (computing)SoftwareData transmissionProcess (computing)

Funding

  • Canada First Research Excellence Fund · CFREF-2022-00042
  • Japan Society for the Promotion of Science · JP25K21333
Perspective and practical signals

Why it matters

Open hardware for accurate liquid transfer in self-driving labs; reports accuracy within ISO 8655-2 permissible error.

Limitations

Requires a robot arm/gripper to operate -- not a standalone bench tool

Skills needed

3D printingbasic assemblyintegration with robot gripper/arm

Democratizing features

open-source hardware and design files available on GitHub, accessible fabrication (3D printed), compatible with standard robotic gripper, compatible with commerical pipette tips which allows for multi-liquid workflows, rapid assembly and modular components, reliable (ISO-compliant accuracy)